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Saccharomyces cerevisiae (S288c)

SPT5

transcription elongation factor SPT5, L000002031, YML010W

Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair

GO Process (8)

GO Function (7)

GO Component (4)

Gene Ontology Biological Process

7-methylguanosine mRNA capping [IGI, IPI]

intracellular mRNA localization [IMP]

mRNA splicing, via spliceosome [IMP]

negative regulation of transcription elongation from RNA polymerase I promoter [IGI]

positive regulation of transcription elongation from RNA polymerase I promoter [IMP]

positive regulation of transcription elongation from RNA polymerase II promoter [IMP]

regulation of rRNA processing [IMP]

regulation of transcription-coupled nucleotide-excision repair [IGI]

Gene Ontology Molecular Function

RNA polymerase I core binding [IPI]
RNA polymerase I transcription factor binding [IPI]
RNA polymerase II core binding [IPI]
core RNA polymerase I binding transcription factor activity [IC]
core RNA polymerase II binding transcription factor activity [IGI, IMP, IPI]
mRNA binding [IDA]
rRNA binding [IDA]

Gene Ontology Cellular Component

DSIF complex [IPI]

mitochondrion [IDA]

rDNA heterochromatin [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

35159

559292

Interactors 236
Interactions 473
Network
PTM Sites 30