Saccharomyces cerevisiae (S288c)

ISY1

NTC30, UTR3, L000002730, YJR050W

Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles

GO Process (2)

GO Function (2)

GO Component (5)

Gene Ontology Biological Process

generation of catalytic spliceosome for second transesterification step [IMP]

mRNA 3'-splice site recognition [IMP]

Gene Ontology Molecular Function

first spliceosomal transesterification activity [IGI]
second spliceosomal transesterification activity [IC]

Gene Ontology Cellular Component

Prp19 complex [IDA]

U2-type catalytic step 1 spliceosome [IDA]

U2-type catalytic step 2 spliceosome [IDA]

post-mRNA release spliceosomal complex [IDA]

post-spliceosomal complex [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

33803

559292

Interactors 204
Interactions 398
Network
PTM Sites 1

Result Summary

ISY1

Gene Ontology Biological Process

Gene Ontology Molecular Function

first spliceosomal transesterification activity [IGI]second spliceosomal transesterification activity [IC]

Gene Ontology Cellular Component

first spliceosomal transesterification activity [IGI]
second spliceosomal transesterification activity [IC]