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Saccharomyces cerevisiae (S288c)

SCM3

L000003281, YDL139C

Nonhistone component of centromeric chromatin; binds to histone H3 variant, Cse4p, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres; required for kinetochore assembly and G2/M progression; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP

GO Process (5)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

G2/M transition of mitotic cell cycle [IMP]

chromosome segregation [IMP]

kinetochore assembly [IMP]

negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]

protein localization to chromosome, centromeric region [IMP]

Gene Ontology Molecular Function

CENP-A containing nucleosome binding [IMP, IPI]

Gene Ontology Cellular Component

condensed nuclear chromosome, centromeric region [IDA, IPI]

cytoplasm [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31922

559292

Interactors 150
Interactions 195
Network