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Saccharomyces cerevisiae (S288c)

SEC61

translocon subunit SEC61, L000001852, YLR378C

Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independent protein import into ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER

GO Process (6)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

ER-associated ubiquitin-dependent protein catabolic process [IMP, IPI]

SRP-dependent cotranslational protein targeting to membrane, translocation [IDA]

intracellular protein transmembrane import [IMP]

misfolded protein transport [IMP]

posttranslational protein targeting to membrane, translocation [IDA, IMP]

retrograde protein transport, ER to cytosol [IMP]

Gene Ontology Molecular Function

P-P-bond-hydrolysis-driven protein transmembrane transporter activity [IDA, IMP]
peptide transporter activity [IMP]
signal sequence binding [IDA]

Gene Ontology Cellular Component

Sec61 translocon complex [IDA]

integral component of membrane [ISM]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31638

559292

Interactors 2,482
Interactions 3,025
Network
PTM Sites 3