Saccharomyces cerevisiae (S288c)

SIR4

ASD1, STE9, UTH2, chromatin-silencing protein SIR4, L000001897, YDR227W
SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan
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  • Interactors 145
  • Interactions 330
  • Network
  • PTM Sites 16