Welcome to PhosphoGRID

PhosphoGRID is an online database of experimentally verified in vivo protein phosphorylation sites in the model eukaryotic organism Saccharomyces cerevisisae. The database includes results from both high throughput (HTP) MS proteomics studies in addition to phosphosites identified in low throughput (LTP) studies of individual proteins or protein complexes. The identity of specific protein kinases and phosphatases shown to regulate appearance of phosphorylations are recorded, where available, as are the function(s) of the phosphorylation, and conditions under which the modification was demonstrated to occur. The PhosphoGRID curators would appreciate comments on omissions and errors, as well as notifications of newly published or submitted data.

This work was supported by:

  • Canadian Institutes of Health Research grant (MOP-77807 - to I.S.)
  • Canadian Cancer Society Research Institute Grant (0011258 to I.S.)
  • Canadian Institutes of Health Research grant (GSP-36651 to M.T.)
  • NIH National Center for Research Resources Grant (1R01RR024031-01 to M.T. and K.D.)


Latest News

BioGRID Version 3.2.109 Release (7,377 New Physical and Genetic Interactions Added)

February 1, 2014 - 10:14 pm

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 7,377 interactions. These additions bring our total number of non-redundant interactions to 506,606 and raw interactions to 732,422. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.108 Release (2,504 New Physical and Genetic Interactions Added)

January 1, 2014 - 10:12 pm

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 2,504 interactions. These additions bring our total number of non-redundant interactions to 500,239 and raw interactions to 725,045. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.106 Release (4,937 New Physical and Genetic Interactions Added)

November 1, 2013 - 2:40 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 4,937 interactions. These additions bring our total number of non-redundant interactions to 500,397 and raw interactions to 722,541. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.105 Release (8,771 New Physical and Genetic Interactions Added)

October 1, 2013 - 6:14 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 8,771 interactions. These additions bring our total number of non-redundant interactions to 496,761 and raw interactions to 717,604. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.104 Release (5,683 New Physical and Genetic Interactions Added)

September 1, 2013 - 3:11 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 5,683 interactions. These additions bring our total number of non-redundant interactions to 490,874 and raw interactions to 708,833. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.103 Release (6,913 New Physical and Genetic Interactions Added)

August 1, 2013 - 8:04 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 6,913 interactions. These additions bring our total number of non-redundant interactions to 487,059 and raw interactions to 703,150. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

Introduction of Proximity label-MS and Proximity label-Western Evidence Codes

July 17, 2013 - 1:25 am

For the 3.2.102 update, the BioGRID has introduced two new experimental evidence codes for in vivo biochemical interactions, termed Proximity label MS (mass spectrometry) and Proximity label-Western. In light of the rapid growth of interaction data generated using proximity labeling, we have assigned the associated evidence codes to distinguish these data types from conventional affinity capture experiments that are followed by mass spectrometry or western blots. The datasets reported in Roux K.J. et al. (2012) (Pubmed: 22412018) and Rhee H.W. et al (2013) (Pubmed: 23371551) have been entered with the proximity label codes.

Definitions for all evidence codes used in BioGRID can be found in our help wiki at BioGRID Help and Support Resources.

BioGRID Version 3.2.102 Release (11,241 New Physical and Genetic Interactions Added)

July 1, 2013 - 1:14 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 11,241 interactions. These additions bring our total number of non-redundant interactions to 482544 and raw interactions to 696,237. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

National Institutes of HealthBiotechnology and Biological Sciences Research CouncilCanadian Institutes of Health ResearchThe University of EdinburghPrinceton UniversitySamuel Lunenfeld Research InstituteSaccharomyces Genome DatabaseFlybaseGeneDBNational Center for Biotechnology InformationHuman Protein Reference DatabaseWormbaseGene OntologyThe International Molecular Exchange ConsortiumDatabase of Interacting ProteinsIntACTMolecular Interaction DatabaseProteomics Standards InitiativeReactomeCytoscapeOsprey Network Visualization SystemPathway Commons