Welcome to PhosphoGRID

PhosphoGRID is an online database of experimentally verified in vivo protein phosphorylation sites in the model eukaryotic organism Saccharomyces cerevisisae. The database includes results from both high throughput (HTP) MS proteomics studies in addition to phosphosites identified in low throughput (LTP) studies of individual proteins or protein complexes. The identity of specific protein kinases and phosphatases shown to regulate appearance of phosphorylations are recorded, where available, as are the function(s) of the phosphorylation, and conditions under which the modification was demonstrated to occur. The PhosphoGRID curators would appreciate comments on omissions and errors, as well as notifications of newly published or submitted data.

This work was supported by:

  • Canadian Institutes of Health Research grant (MOP-77807 - to I.S.)
  • Canadian Cancer Society Research Institute Grant (0011258 to I.S.)
  • Canadian Institutes of Health Research grant (GSP-36651 to M.T.)
  • NIH National Center for Research Resources Grant (1R01RR024031-01 to M.T. and K.D.)


Latest News

BioGRID Version 3.2.119 Release (17,061 New Physical and Genetic Interactions Added)

December 1, 2014 - 6:35 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 17,061 interactions from 44,135 publications. These additions bring our total number of non-redundant interactions to 557,158 and raw interactions to 804,431. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.118 Release (7,077 New Physical and Genetic Interactions Added)

November 1, 2014 - 3:59 pm

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 7,077 interactions from 43,913 publications. These additions bring our total number of non-redundant interactions to 543,666 and raw interactions to 787,370. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.117 Release (5,989 New Physical and Genetic Interactions Added)

October 1, 2014 - 6:55 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 5,989 interactions from 43,646 publications. These additions bring our total number of non-redundant interactions to 544,367 and raw interactions to 785,449. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

New Dataset of 23,756 Human Affinity Capture-MS Interactions

September 5, 2014 - 1:51 am

The BioGRID has posted a new dataset of 23,756 new human protein interactions detected by affinity capture-mass spectrometry, as reported by the groups of Steve Gygi and Wade Harper in the pre-publication dataset: “High Throughput Proteomic Mapping of Human Interaction Networks via Affinity-Purification Mass Spectrometry (2014)“. The dataset and associated quantitative scores are available immediately online via all standard BioGRID searches, and will be incorporated into all supported download formats upon publication.

A special thanks to the contributors Edward L. Huttlin (1), Lily Ting (1), Raphael J. Bruckner (1), Joao A. Paulo (1), Melanie P. Gygi (1), Ramin Rad (1), Deepak Kolippakkam (1), John Szpyt (1), Gabriela Zarraga (1), Stanley Tam (1), Fana Gebreab (1), Greg Colby (1), Laura Pontano-Vaites (1), Robert A. Obar (1), Virginia Guarani-Pereira (1), Timothy Harris (2), Spyros Artavanis-Tsakonas (2), Mathew E. Sowa (1), J. Wade Harper (1), and Steven P. Gygi (1) from the (1) Department of Cell Biology, Harvard Medical School and (2) Biogen-Idec, Cambridge for providing the dataset. This work was supported by grants to S.P.G. and J.W.H. from Biogen-Idec and NIH (U41 HG006673).

If you have an interaction dataset you’d like to deposit directly into the BioGRID, please contact us at biogridadmin@gmail.com.

BioGRID Version 3.2.116 Release (33,848 New Physical and Genetic Interactions Added)

September 1, 2014 - 8:40 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 33,848 interactions from 43,468 publications. These additions bring our total number of non-redundant interactions to 543,431 and raw interactions to 783,760. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.115 Release (2,398 New Physical and Genetic Interactions Added)

August 1, 2014 - 6:22 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 2,398 interactions. These additions bring our total number of non-redundant interactions to 515,032 and raw interactions to 749,912. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.114 Release (5,503 New Physical and Genetic Interactions Added)

July 1, 2014 - 2:20 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 5,503 interactions. These additions bring our total number of non-redundant interactions to 513,924 and raw interactions to 747,514. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

BioGRID Version 3.2.113 Release (483 New Physical and Genetic Interactions Added)

June 1, 2014 - 4:19 am

The BioGRID‘s curated set of physical and genetic interactions has been updated to include an additional 483 interactions. These additions bring our total number of non-redundant interactions to 512,392 and raw interactions to 742,011. New interactions will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these interactions, visit our download page.

National Institutes of HealthBiotechnology and Biological Sciences Research CouncilCanadian Institutes of Health ResearchThe University of EdinburghPrinceton UniversitySamuel Lunenfeld Research InstituteSaccharomyces Genome DatabaseFlybaseGeneDBNational Center for Biotechnology InformationHuman Protein Reference DatabaseWormbaseGene OntologyThe International Molecular Exchange ConsortiumDatabase of Interacting ProteinsIntACTMolecular Interaction DatabaseProteomics Standards InitiativeReactomeCytoscapeOsprey Network Visualization SystemPathway Commons